ARYL HYDROCARBON RECEPTOR MODULATOR

The invention discloses an aryl hydrocarbon receptor modulators of formula (I), and pharmaceutically acceptable salts thereof,R' is H, CN, CH2(OH)R0, CmH2m+1, CnH2n-1, CnH2n-3,two Rais independently H, or two Ratogether form =O or =N-W3-R1; A is a C6to C10aromatic ring, or a C2to C10heteroaroma...

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Bibliographic Details
Main Authors YANG, Luqing, LI, Guodong, ZHANG, Suoming
Format Patent
LanguageEnglish
French
German
Published 09.09.2020
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention discloses an aryl hydrocarbon receptor modulators of formula (I), and pharmaceutically acceptable salts thereof,R' is H, CN, CH2(OH)R0, CmH2m+1, CnH2n-1, CnH2n-3,two Rais independently H, or two Ratogether form =O or =N-W3-R1; A is a C6to C10aromatic ring, or a C2to C10heteroaromatic ring containing 1 to 5 heteroatom selected from N, O and S, or 4 to 7 membered non-aromatic heterocyclic ring containing 1 to 3 heteroatom selected from N, O and S and C=N, which are with no substituent or substituted by 1 or 3 R; Q is R, or a C6to C10aromatic ring or a C2to C10heteroaromatic ring containing 1 to 5 heteroatom selected from N, O and S, which are with no substituent or substituted by 1 or 3 R; R is Rcconnected with C or RNconnected with N. Compounds of this invention of formula (I) can modulate activity of AhR for inhibiting growth of cancer cell and inhibiting migration and invasion of tumour cell.
Bibliography:Application Number: EP20170885769