ORAL PHARMACEUTICAL COMPOSITION WITH IMPROVED TASTE-MASKING PROPERTIES

The invention provides a pharmaceutical composition for the taste-masking of poorly soluble drug substances wherein a melt of a poorly tasting drug is sorbed by water- dispersible, at least partially hydrophilic polymeric carrier particles. Prior to oral consumption, these drug-melt-treated polymeri...

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Bibliographic Details
Main Authors GARSUCH, Verena, HAALA, Josef
Format Patent
LanguageEnglish
French
German
Published 30.10.2019
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The invention provides a pharmaceutical composition for the taste-masking of poorly soluble drug substances wherein a melt of a poorly tasting drug is sorbed by water- dispersible, at least partially hydrophilic polymeric carrier particles. Prior to oral consumption, these drug-melt-treated polymeric carrier particles can be dispersed easily in water, yielding a drink suspension with a neutral taste. Alternatively, the drug-melt-treated polymeric carrier particles may be mixed with further excipients such as sugars, sweeteners or flavourants to provide a dosage form which upon dispersion lends a pleasant taste to the aqueous dispersion medium. The invention further provides an improved process for the preparation of these taste-masked compositions and dosage forms, for instance in heatable vacuum granulators.
Bibliography:Application Number: EP20170825506