THE METHOD FOR IMPROVEMENT OF RESPONSIVENESS OF CELLS TO ULTRASOUND AND MECHANICAL STIMULI WITH GAS VESICLES AND SENSITISED MECHANOSENSORS

The invention relates to the method of enhancement of cells' sensitivity to ultrasound or other, direct or indirect, mechanical stimulus. The method includes spontaneously assembled genetically encoded gas vesicle forming proteins expressed by cells coexpressing or not additional mechanosensory...

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Main Authors MERLJAK, Estera, PRAZNIK, Arne, CEROVIC, Kosta, FINK, Tina, LONZARIC, Jan, LEBAR, Tina, KRESE, Rok, FRANKO, Nik, STRMSEK, Ziga, PLAPER, Tjasa, JERALA, Nina, PUSNIK, Ziga, GRADISEK, Miha, MESKO, Maja, LEBEN, Katja, BENCINA, Mojca, MAGDEVSKA, Lidija, JERALA, Roman, ROSKAR, Samo, LAPENTA, Fabio
Format Patent
LanguageEnglish
French
German
Published 14.08.2019
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:The invention relates to the method of enhancement of cells' sensitivity to ultrasound or other, direct or indirect, mechanical stimulus. The method includes spontaneously assembled genetically encoded gas vesicle forming proteins expressed by cells coexpressing or not additional mechanosensory ion channels. Gas vesicles boost the effect of a mechanical perturbance inside the cell that affects mechanosensory channels and activates intracellular protin cascades. The invention relates to cells expressing gas vesicles with or without additionally expressing mechanosensnsitive ion channels.
Bibliography:Application Number: EP20170797433