SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS

Provided herein are compounds of the Formula I:or pharmaceutically acceptable salt or solvate thereof, wherein A, B, X1, X2, X3, X4, Ring D, E, Ra, Rb, n and m have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases...

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Main Authors ANDREWS, Steven W, ARONOW, Sean, COOK, Adam, MORENO, David A, BLAKE, James F, KOLAKOWSKI, Gabrielle R, COLLIER, James, MCKNULTY, Oren T, BRANDENHUBER, Barbara J, RAMANN, Ginelle A, REN, Li, HAAS, Julia, JIANG, Yutong, MCKENNEY, Megan L, WALLS, Shane M, METCALF, Andrew T, TANG, Tony P, MCFADDIN, Elizabeth A
Format Patent
LanguageEnglish
French
German
Published 14.08.2019
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Provided herein are compounds of the Formula I:or pharmaceutically acceptable salt or solvate thereof, wherein A, B, X1, X2, X3, X4, Ring D, E, Ra, Rb, n and m have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.
Bibliography:Application Number: EP20170787844