PYRIDYL SUBSTITUTED INDOLE COMPOUNDS

Disclosed are compounds of Formula (I) N-oxide, or salt thereof, wherein R1, R2, R3, R4, R5, m, n, and p are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compoun...

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Main Authors DODD, Dharmpal S, HAQUE, Tasir Shamsul, HEGDE, Subramaya, POSS, Michael A, LOMBARDO, Louis J, TORTOLANI, David R, MUSSARI, Christopher P, SISTLA, Ramesh Kumar, RAMACHANDRA, Anupama, PASUNOORI, Laxman, WHITELEY, Brian, RATNA KUMAR, Sreekantha, POSY, Shoshana L, DYCKMAN, Alaric J, MACOR, John E
Format Patent
LanguageEnglish
French
German
Published 17.11.2021
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Disclosed are compounds of Formula (I) N-oxide, or salt thereof, wherein R1, R2, R3, R4, R5, m, n, and p are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.
Bibliography:Application Number: EP20170768623