USE OF EPIGENETIC INHIBITOR 1-(BETA-D-RIBOFURANOSYL)-2(1H)-PYRIMIDINONE (ZEBULARINE) FOR PROMOTING WOUND HEALING, COMPLEX TISSUE AND ORGAN REGENERATION

In one aspect, the invention provides a composition comprising zebularine, a nucleotide inhibitor of DNA methyltransferase, optionally in combination with retinoic acid, and said composition for use in promoting complex tissue regeneration and wound healing in a subject.In another aspect the present...

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Main Authors Skowron, Piotr, Sass, Piotr, Mucha, Piotr, Janus, Lukasz, Podolak-Popinigis, Justyna, Rodziewicz-Motowidlo, Sylwia, Sachadyn, Pawel, Piotrowski, Arkadiusz, Gornikiewicz, Bartosz, Sosnowski, Pawel, Czypryn, Artur, Pikula, Michal
Format Patent
LanguageEnglish
French
German
Published 05.06.2019
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Abstract In one aspect, the invention provides a composition comprising zebularine, a nucleotide inhibitor of DNA methyltransferase, optionally in combination with retinoic acid, and said composition for use in promoting complex tissue regeneration and wound healing in a subject.In another aspect the present invention provides zebularine as a therapeutic agent, optionally in combination with retinoic acid, for use in promoting regeneration and healing of wounds resulting from mechanical injuries and/or chemical injuries and/or burns and/or radiation injuries and/or surgical operations and/or other pathological conditions.
AbstractList In one aspect, the invention provides a composition comprising zebularine, a nucleotide inhibitor of DNA methyltransferase, optionally in combination with retinoic acid, and said composition for use in promoting complex tissue regeneration and wound healing in a subject.In another aspect the present invention provides zebularine as a therapeutic agent, optionally in combination with retinoic acid, for use in promoting regeneration and healing of wounds resulting from mechanical injuries and/or chemical injuries and/or burns and/or radiation injuries and/or surgical operations and/or other pathological conditions.
Author Gornikiewicz, Bartosz
Czypryn, Artur
Piotrowski, Arkadiusz
Rodziewicz-Motowidlo, Sylwia
Sass, Piotr
Skowron, Piotr
Sachadyn, Pawel
Pikula, Michal
Podolak-Popinigis, Justyna
Mucha, Piotr
Janus, Lukasz
Sosnowski, Pawel
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– fullname: Sachadyn, Pawel
– fullname: Piotrowski, Arkadiusz
– fullname: Gornikiewicz, Bartosz
– fullname: Sosnowski, Pawel
– fullname: Czypryn, Artur
– fullname: Pikula, Michal
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DocumentTitleAlternate VERWENDUNG DES EPIGENETISCHEN INHIBITORS 1-(BETA-D-RIBOFURANOSYL)-2(1H)-PYRIMIDINON (ZEBULARIN) ZUR FÖRDERUNG DER WUNDHEILUNG, DER KOMPLEXEN GEWEBE- UND ORGANREGENERATION
UTILISATION DE L'INHIBITEUR ÉPIGÉNÉTIQUE 1-(BETA-D-RIBOFURANOSYL)-2(1H)-PYRIMIDINONE (ZEBULARINE) POUR FAVORISER LA CICATRISATION DES PLAIES, LA RÉGÉNÉRATION DE TISSUS COMPLEXES ET D'ORGANES
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RelatedCompanies Instytut Biologii Doswiadczalnej im. Marcelego Nenckiego Polskiej Akademii Nauk
Gdanski Uniwersytet Medyczny
MEDVentures sp. z. o. o
Politechnika Gdanska
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Uniwersytet Gdanski
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– name: Gdanski Uniwersytet Medyczny
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Snippet In one aspect, the invention provides a composition comprising zebularine, a nucleotide inhibitor of DNA methyltransferase, optionally in combination with...
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SubjectTerms HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title USE OF EPIGENETIC INHIBITOR 1-(BETA-D-RIBOFURANOSYL)-2(1H)-PYRIMIDINONE (ZEBULARINE) FOR PROMOTING WOUND HEALING, COMPLEX TISSUE AND ORGAN REGENERATION
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