USE OF EPIGENETIC INHIBITOR 1-(BETA-D-RIBOFURANOSYL)-2(1H)-PYRIMIDINONE (ZEBULARINE) FOR PROMOTING WOUND HEALING, COMPLEX TISSUE AND ORGAN REGENERATION

• Main Authors: Skowron, Piotr, Sass, Piotr, Mucha, Piotr, Janus, Lukasz, Podolak-Popinigis, Justyna, Rodziewicz-Motowidlo, Sylwia, Sachadyn, Pawel, Piotrowski, Arkadiusz, Gornikiewicz, Bartosz, Sosnowski, Pawel, Czypryn, Artur, Pikula, Michal
• Format: Patent
• Language: English; French; German
• Published: 05.06.2019
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

In one aspect, the invention provides a composition comprising zebularine, a nucleotide inhibitor of DNA methyltransferase, optionally in combination with retinoic acid, and said composition for use in promoting complex tissue regeneration and wound healing in a subject.In another aspect the present invention provides zebularine as a therapeutic agent, optionally in combination with retinoic acid, for use in promoting regeneration and healing of wounds resulting from mechanical injuries and/or chemical injuries and/or burns and/or radiation injuries and/or surgical operations and/or other pathological conditions.