NOVEL 5H-PYRROLO[2,3-D]PYRIMIDIN-6(7H)-ONE DERIVATIVE

• Main Authors: YAMAMOTO Fuyuki, SAKAMOTO Toshihiro, KOBAYAKAWA Yu, EGASHIRA Naoki, MACHIDA Takumitsu, SUGIMOTO Tetsuya, ICHIKAWA Koji
• Format: Patent
• Language: English; French; German
• Published: 08.01.2020
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention of the present application provides a compound represented by Formula (I) or a salt thereof, which exhibits an inhibitory activity against at least one kinase selected from the group consisting of Akt kinase, Rsk kinase, and S6K kinase and/or a cell proliferation inhibiting effect and is useful as a prophylactic and/or therapeutic agent for diseases associated with the above-mentioned kinases, particularly cancer. [In the formula, R 1 represents a 4- to 6-membered monocyclic unsaturated heterocyclic group which has 1 to 3 hetero atoms independently selected from N, S and O and may have a substituent; R 2 represents a hydrogen atom or the like; R 3 , R 4 , and R 5 , may be the same as or different from one another and independently represent a hydrogen atom or the like; R 6 represents a hydrogen atom or the like; R 7 and R 8 , may be the same as or different from each other and independently represent a hydrogen atom or the like; X 1 and X 2 may be the same as or different from each other and independently represent N or CR 9 ; R 9 represents a hydrogen atom or the like; and X 3 represents N or CH when the broken line ( --- ) represents a single bond, and represents C when a broken line indicates a double bond, wherein at least one of X 1 or X 2 represents N.]