PROCESS FOR PREPARING AD-35

Disclosed are a method for preparing a benzodioxole derivative (AD-35) shown by Formula (I) and an intermediate thereof. The method of the present invention involves: using piperic acid as a raw material; and performing bromination, esterification, cyanidation, cyclopropane lactamization, amide nitr...

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Bibliographic Details
Main Authors GONG, Yongxiang, BAI, Hua, ZHAO, Xuyang, LIU, Weiwei, ZHU, Qifeng, ZHOU, Ya, ZHONG, Jinqing, ZHANG, Xinlong
Format Patent
LanguageEnglish
French
German
Published 20.02.2019
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Disclosed are a method for preparing a benzodioxole derivative (AD-35) shown by Formula (I) and an intermediate thereof. The method of the present invention involves: using piperic acid as a raw material; and performing bromination, esterification, cyanidation, cyclopropane lactamization, amide nitrogen alkylation, deprotection, piperidine nitrogen alkylation and salification to obtain the compound of Formula (I). The method has cheap and easily available start raw materials, short synthesis routes and simple operation, and is suitable for industrial production.
Bibliography:Application Number: EP20170781792