HADD, A NOVEL PROTEIN OF THE MYCOBACTERIAL FATTY ACID SYNTHASE TYPE II

The application to a protein, which has been termed HadD by the inventors. HadD is an enzyme, which is involved in the biosynthesis of the mycobacterial envelope. A hadD orthologue is present in Non-Tuberculous Mycobacteria (NTM), as well as in tuberculous mycobacteria of the M. tuberculosis complex...

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Main Authors QUEMARD, Annaïk, BURLET-SCHILTZ, Odile, BARDOU, Fabienne, EYNARD, Nathalie, DUCOUX-PETIT, Manuelle, LEFEBVRE, Cyril, BOUSQUET, Marie-Pierre, BOULON, Richard, DAFFE, Mamadou, GAVALDA, Sabine
Format Patent
LanguageEnglish
French
German
Published 06.02.2019
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMES
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:The application to a protein, which has been termed HadD by the inventors. HadD is an enzyme, which is involved in the biosynthesis of the mycobacterial envelope. A hadD orthologue is present in Non-Tuberculous Mycobacteria (NTM), as well as in tuberculous mycobacteria of the M. tuberculosis complex and in M. leprae. The application also relates to products and means, which involve or derive from the HadD protein, such as ligands. The application also relates to applications of said HadD protein, or of said products or means, notably for the identification of anti-mycobacterial compounds or for the treatment of mycobacterial diseases, more particularly of a NTM infection, tuberculosis or leprosy.
Bibliography:Application Number: EP20170306041