INHIBITORS OF INFLUENZA VIRUSES REPLICATION

• Main Authors: JACOBS, Dylan H, WANG, Tiansheng, WANNAMAKER, Woods M, LEDFORD, Brian, COURT, John J, KENNEDY, Joseph M, LIN, Chao, GERMANN, Ursula A, SALITURO, Francesco G, CLARK, Michael P, BANDARAGE, Upul K, BETHIEL, Randy S, DUFFY, John. P, GAO, Huai, MALTAIS, Francois, JONES, Steven, KWONG, Ann Dak-Yee, GU, Wenxin, PEROLA, Emanuele, FARMER, Luc, BYRN, Randal, DENG, Hongbo, ZHOU, Yi, CHARIFSON, Paul, JIANG, Min, LEDEBOER, Mark W, DRUTU, Ioana
• Format: Patent
• Language: English; French; German
• Published: 01.12.2021
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula ( I ): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A compound is represented by Structural Formula ( IA ) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula ( IA ) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.