SUBSTITUTED INDOLE MCL-1 INHIBITORS

The present disclosure provides for compounds that inhibit the activity of an anti-apoptotic Bcl-2 family member Myeloid cell leukemia-1 (Mcl-1) protein. The present disclosure also provides for pharmaceutical compositions as well as methods for using compounds for treatment of diseases and conditio...

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Bibliographic Details
Main Authors LEE, Taekyu, SALOVICH, James, M, CHRISTOV, Plamen, P, FESIK, Stephen, W, KIM, Kwangho, SHAW, Subrata, TARR, James, C, ZHAO, Bin, VEERASAMY, Nagarathanam, OLEJNICZAK, Edward, T, JEON, Kyuok, BIAN, Zhiguo
Format Patent
LanguageEnglish
French
German
Published 23.08.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present disclosure provides for compounds that inhibit the activity of an anti-apoptotic Bcl-2 family member Myeloid cell leukemia-1 (Mcl-1) protein. The present disclosure also provides for pharmaceutical compositions as well as methods for using compounds for treatment of diseases and conditions (e.g., cancer) characterized by the over-expression or dysregulation of Mcl-1 protein.
Bibliography:Application Number: EP20170760914