PEPTIDE AGONISTS AND ANTAGONISTS OF TLR4 ACTIVATION

A group of peptides is provided which activate or inhibit toll-like receptor 4 (TLR4) and may be used to modulate inflammatory signaling and host defense pathways. The peptides were derivedin silicoand testedin vitroin cell cultures. These peptides may be used in the preparation of immunomodulatory...

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Bibliographic Details
Main Authors RUPP, Steffen, MICHAELI, Amit, BURGER-KENTISCHER, Anke, LERNER, Immanuel
Format Patent
LanguageEnglish
French
German
Published 26.02.2020
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:A group of peptides is provided which activate or inhibit toll-like receptor 4 (TLR4) and may be used to modulate inflammatory signaling and host defense pathways. The peptides were derivedin silicoand testedin vitroin cell cultures. These peptides may be used in the preparation of immunomodulatory compositions such as vaccine adjuvants and in pharmaceutical compositions for immunomodulation of the innate immune system such as vaccine adjuvants. The peptides may also be used in the preparation of TLR4 activators, TLR4 inhibitors and MD2 labels, e.g., for research purposes.
Bibliography:Application Number: EP20170752801