NITROGEN-CONTAINING HETEROCYCLE AND CARBOCYCLE DERIVATIVES HAVING TRKA INHIBITORY ACTIVITY

The present invention provides a compound having TrkA inhibitory activity, or a pharmaceutically acceptable salt thereof. The present invention relates to a compound represented by Formula (I): wherein =X is =O or the like, R 5 and R 5A are hydrogen atoms or the like, -A- is -NR 1 - or the like, B i...

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Main Authors NAKAMURA, Kenichiroh, FUJIU, Motohiro, HORIGUCHI, Tohru, YUKIMASA, Akira, YAMAGUCHI, Hiroki, INOUE, Takatsugu, KANO, Kazuya
Format Patent
LanguageEnglish
French
German
Published 07.09.2022
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides a compound having TrkA inhibitory activity, or a pharmaceutically acceptable salt thereof. The present invention relates to a compound represented by Formula (I): wherein =X is =O or the like, R 5 and R 5A are hydrogen atoms or the like, -A- is -NR 1 - or the like, B is substituted or unsubstituted aromatic carbocyclyl or the like, R 1 is substituted or unsubstituted alkyl or the like, R 2 is a hydrogen atom or the like, -W-is -CH 2 - or the like, -W A - is -CH 2 - or the like, R 13 is substituted or unsubstituted aromatic carbocyclyl or the like, R 14 is substituted or unsubstituted aromatic heterocyclyl or the like, R 15 is substituted or unsubstituted alkyl or the like, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing the same.
Bibliography:Application Number: EP20170747550