MASSIVELY PARALLEL DNA SEQUENCING APPARATUS

The present invention provides a method of making a genome or DNA sequencing device, the method comprising the steps of:(a) disposing an array of electrode pairs (71) on a substrate, each electrode within a given pair of electrodes having a tip-shaped end, with the electrodes in each pair separated...

Full description

Saved in:
Bibliographic Details
Main Authors MOLA, Paul, W, MERRIMAN, Barry, L, JIN, Sungho, CHOI, Chulmin
Format Patent
LanguageEnglish
French
German
Published 26.02.2020
Subjects
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
Online AccessGet full text

Cover

More Information
Summary:The present invention provides a method of making a genome or DNA sequencing device, the method comprising the steps of:(a) disposing an array of electrode pairs (71) on a substrate, each electrode within a given pair of electrodes having a tip-shaped end, with the electrodes in each pair separated by a nanogap defined by tip-shaped ends facing one another;(b) electrodepositing gold at each tip-shaped end by applying a voltage to the electrode pair whereby high current density in the region of each tip-shaped end of each electrode directs preferential electrodeposition of gold to each tip-shaped end to form a gold nano-tip on each electrode; and(c) attaching each end of a biomolecule having two ends to the gold nano-tips such that one biomolecule bridges over each nanogap in each electrode pair.
Bibliography:Application Number: EP20170745013