METHOD FOR PREPARING METHIONINE ANALOGUES

• Main Authors: REY, Patrick, AIRIAU, Etienne, MONBRUN, Jérôme, HENRYON, Vivien, AUBRY, Sylvain, HUET, Robert
• Format: Patent
• Language: English; French; German
• Published: 28.11.2018
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

The invention relates to a method for preparing a compound (I) or one of the salts thereof, and the uses of said method, R1OOC-C(═X)-CHR2R3(I), wherein X is selected among O; N-R′, wherein R′ is H or a C1-C6 alkyl; and N-OR″ wherein R″ is H, or a C1-C6 alkyl or an alkylaryl; R1 is H or a C1-C6 alkyl group; R2 is H, a C1-C6 alkyl, or an alkylaryl; and R3 is CH2SR4 or CH2SeR4, where R4 is H or a C1-C6 alkyl from a compound (II), or one of the salts thereof, R1OOC-C(═X)-CHR2R5 and R5 is H or COOR6, where R6 is H or a C1-C6 alkyl, said method being carried out in the presence of a compound (III) CH2(Y)(Z). Wherein Y is H; OR7, where R7 is H, a C1-C6 alkyl or an acyl with formula CO-R4; SR4 or SeR4 where R4 matches the preceding definition; or 1 NR8R9, where R8 and R9, identical or different, each or together are a C1-C6 alkyl, or an alkylaryl; Z, identical or different to Y, is OR10 where R10 is H, a C1-C6 alkyl or CO-R4; a cyclic or acyclic N(COR4)(COR4) group; or NR11R12, where R11 and R12, identical or different, each or together are a C1-C6 alkyl or an alkylaryl; wherein Y and Z together are ═O; said method involving an intermediate product (IV) R1OOC-C(═X)-CHR2-CH2Z.