OXAZOLIDINONES AS TARO INHIBITORS

Novel compounds of the structural formula I, and the pharmaceutically acceptable salts thereof, are inhibitors of TarO and may be useful in the prevention, treatment and suppression of diseases mediated by TarO, such as bacterial infections, including gram negative bacterial infections and gram posi...

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Main Authors DE JESUS, Reynalda, MANDAL, Mihir, LABROLI, Marc A, TANG, Haifeng, HA, Sookhee N, MADSEN-DUGGAN, Christina, LEE, Sang Ho, WANG, Hao, CALDWELL, John P, DING, Fa-Xiang, GILL, Charles J, TAN, Zheng, KOSEOGLU, Sandra, J, SU, Jing, TAN, Christopher Michael, YANG, Shu-Wei, HO, Ginny Dai, YANG, Christine, ROEMER, Terry
Format Patent
LanguageEnglish
French
German
Published 13.12.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Novel compounds of the structural formula I, and the pharmaceutically acceptable salts thereof, are inhibitors of TarO and may be useful in the prevention, treatment and suppression of diseases mediated by TarO, such as bacterial infections, including gram negative bacterial infections and gram positive bacterial infections such as MRSA and MRSE, alone or in combination with a β-lactam antibiotic.
Bibliography:Application Number: EP20160876469