SUBSTITUTED TRIAZOLOPIPERAZINE PARP INHIBITOR, PREPARATION METHOD THEREFOR, AND USE THEREOF

The present invention relates to a class of substituted triazolopiperazine compounds represented by formula ( I ), tautomers, enantiomers, diastereomers, racemates, metabolites, metabolic precursors, and pharmaceutically acceptable salts, esters, prodrugs or hydrate thereof, a preparation methods th...

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Main Authors SONG, Shanshan, DING, Jian, SONG, Zilan, MIAO, Zehong, ZHANG, Ao, WANG, Pingyuan, FAN, Zhoulong, HUAN, Xiajuan
Format Patent
LanguageEnglish
French
German
Published 03.10.2018
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to a class of substituted triazolopiperazine compounds represented by formula ( I ), tautomers, enantiomers, diastereomers, racemates, metabolites, metabolic precursors, and pharmaceutically acceptable salts, esters, prodrugs or hydrate thereof, a preparation methods therefor, intermediates and a use thereof in the preparation of drugs for prevention and treatment of diseases associated with PARP including various ischemic diseases, neurodegenerative diseases and cancers.
Bibliography:Application Number: EP20160867946