COMPLEX OF ANGIOTENSIN RECEPTOR ANTAGONIST AND NEUTRAL ENDOPEPTIDASE INHIBITOR

Provided a complex of formula is [3-((1S, 3R)-1-biphenyl-4-ylmethyl-3-ethoxycarbonyl-1-butylcarbamoyl) propionate- (S)-3'-methyl-2'- (pentanoyl {2''-(tetrazol-5-ylate) biphenyl-4'-ylmethyl}amino) butyrate] 6·XCa2+·YNa+·ZH2O, wherein X＝1-3, Y＝12-16, Z＝9-18, and 2X+Y＝18, and r...

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Main Authors WANG, Ying, JIA, Jianjing, CEN, Guodong, DONG, Qing, YANG, Haitao, HUANG, Long, LIU, Qiangqiang, LIU, Yang, LI, Jianguo, XIANG, Yongzhe
Format Patent
LanguageEnglish
French
German
Published 17.07.2019
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Provided a complex of formula is [3-((1S, 3R)-1-biphenyl-4-ylmethyl-3-ethoxycarbonyl-1-butylcarbamoyl) propionate- (S)-3'-methyl-2'- (pentanoyl {2''-(tetrazol-5-ylate) biphenyl-4'-ylmethyl}amino) butyrate] 6·XCa2+·YNa+·ZH2O, wherein X＝1-3, Y＝12-16, Z＝9-18, and 2X+Y＝18, and represented by formula (I). Also disclosed are the method of preparing the complex and the method of treating chronic heart disease using a medicament comprising the complex.
Bibliography:Application Number: EP20160863468