CONJUGATES COMPRISING SELF-IMMOLATIVE GROUPS AND METHODS RELATED THERETO

In some aspects, the invention relates to an antibody-drug conjugate, comprising an antibody; a linker; and an active agent. The antibody-drug conjugate may comprise a self-immolative group. The linker may comprise an O-substituted oxime, e.g., wherein the oxygen atom of the oxime is substituted wit...

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Main Authors OH, Yeong Soo, LEE, Su In, WOO, Dong Hyun, PARK, Yun Hee, KIM, Hyoungrae, KIM, Sung, Min, JUN, Ji Eun, KIM, Yong Zu, PARK, Kyung Eun, CHAE, Jeiwook, KIM, Jinyeong, CHUNG, Chul-Woong, LEE, Byung Soo, CHOI, Hyo Jung, SONG, Ho Young, MIN, Ji, Young
Format Patent
LanguageEnglish
French
German
Published 03.04.2024
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:In some aspects, the invention relates to an antibody-drug conjugate, comprising an antibody; a linker; and an active agent. The antibody-drug conjugate may comprise a self-immolative group. The linker may comprise an O-substituted oxime, e.g., wherein the oxygen atom of the oxime is substituted with a group that covalently links the oxime to the active agent; and the carbon atom of the oxime is substituted with a group that covalently links the oxime to the antibody.
Bibliography:Application Number: EP20160868091