STABILIZER AND STABILIZATION METHOD

It is an object to provide a stabilizer for 8-amino-5-chloro-7-phenylpyrido[3,4-d]pyridazine-1,4(2H,3H)-dione (L-012) or a salt thereof, and the like, which does not give an adverse effect during measurements and can suppress a decrease in measurement sensitivity due to exposure by coexisting with t...

Full description

Saved in:
Bibliographic Details
Main Authors YAMAMOTO Naoyuki, OHASHI Toshinari, KAJI Shinya
Format Patent
LanguageEnglish
French
German
Published 03.07.2019
Subjects
Online AccessGet full text

Cover

Loading…
More Information
Summary:It is an object to provide a stabilizer for 8-amino-5-chloro-7-phenylpyrido[3,4-d]pyridazine-1,4(2H,3H)-dione (L-012) or a salt thereof, and the like, which does not give an adverse effect during measurements and can suppress a decrease in measurement sensitivity due to exposure by coexisting with the stabilizer and L-012 or a salt thereof. The present invention relates to a stabilizer for L-012 or a salt thereof, represented by the general formula [1], a stabilization method for L-012 or a salt thereof, coexisting with the stabilizer and L-012 or a salt thereof, and the like. wherein, p pieces of M 1 each independently represent a hydrogen atom or an alkali metal atom, q pieces of R 1 each independently represent a hydroxy group or a sulfonic acid group, m represents 0 or 1, p represents an integer of 1 to 3, q represents an integer of 0 to 4, Y represents a nitrogen atom or a CH group (a methine group), and Z represents an aryl group having a specific structure or a pyrazolyl group having a specific structure.
Bibliography:Application Number: EP20160857505