BICYCLIC HETEROCYCLES AS INHIBITORS OF CHOLESTEROL ESTER TRANSFER PROTEIN

The invention provides compounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, wherein D1, D2, D3, X, Y, A1, A2, R1, R5 and the subscript a are as described herein. The compounds are CETP inhibitors and are useful for raising FIDL-cholesterol, reduc...

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Bibliographic Details
Main Authors THATAI, Jayanth Thiruvellore, VACHAL, Petr, SHAO, Pengcheng Patrick, SARKAR, Sujit Kumar, KATIPALLY, Revathi Reddy
Format Patent
LanguageEnglish
French
German
Published 23.05.2018
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The invention provides compounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, wherein D1, D2, D3, X, Y, A1, A2, R1, R5 and the subscript a are as described herein. The compounds are CETP inhibitors and are useful for raising FIDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis:
Bibliography:Application Number: EP20160824927