A TWO-STEP PROCESS FOR PREPARING 3-SUBSTITUTED PHENYLALKYLAMINES

Processes for preparing 3-substituted phenylalkylamines comprising reacting a phenyl boronic compound with an α-β unsaturated carbonyl-containing compound via an asymmetric 1, 4-addition reaction, followed by reductive alkylation. The processes may be useful in the synthesis of tapentadol.

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Bibliographic Details
Main Authors TERAMURA, Doug, LIAO, Subo
Format Patent
LanguageEnglish
French
German
Published 29.12.2021
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Processes for preparing 3-substituted phenylalkylamines comprising reacting a phenyl boronic compound with an α-β unsaturated carbonyl-containing compound via an asymmetric 1, 4-addition reaction, followed by reductive alkylation. The processes may be useful in the synthesis of tapentadol.
Bibliography:Application Number: EP20160824898