THERAPEUTIC ISOXAZOLE COMPOUNDS

The invention provides a compound of formula I: wherein A 1 , A 2 , A 3 , R 1 , X , Y , and B have any of the values described herein, as well as salts of such compounds, compositions comprising such compounds, and therapeutic methods that comprise the administration of such compounds. The compounds...

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Bibliographic Details
Main Authors KEENAN, Terence P, KAPLAN, Alan P, MCRINER, Andrew J
Format Patent
LanguageEnglish
French
German
Published 25.04.2018
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention provides a compound of formula I: wherein A 1 , A 2 , A 3 , R 1 , X , Y , and B have any of the values described herein, as well as salts of such compounds, compositions comprising such compounds, and therapeutic methods that comprise the administration of such compounds. The compounds are inhibitors of monoamine oxidase B (MAO-B) enzyme function and are useful for improving cognitive function and for treating psychiatric disorders in animals.
Bibliography:Application Number: EP20170204892