COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF SHP2

in which Y1, Y2, Y3, R1, R2, R4a, R5b, R5a, R5b, R6a and R6b are defined in the Summary of the Invention; capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and...

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Bibliographic Details
Main Authors LAMARCHE, Matthew J, SENDZIK, Martin, PALERMO, Mark G, TOURE, Bakary-Barry, CHEN, Zhuoliang, PEREZ, Lawrence Blas, JOUK, Andriana, SARVER, Patrick James, FORTANET, Jorge Garcia, LIU, Gang, YU, Bing, KARKI, Rajesh, SHULTZ, Michael David
Format Patent
LanguageEnglish
French
German
Published 29.04.2020
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:in which Y1, Y2, Y3, R1, R2, R4a, R5b, R5a, R5b, R6a and R6b are defined in the Summary of the Invention; capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.
Bibliography:Application Number: EP20160731666