NITROGEN-CONTAINING TRICYCLIC DERIVATIVE HAVING HIV REPLICATION INHIBITORY ACTIVITY

The present invention provides a novel compound having antiviral activity, especially HIV replication inhibitory activity and a medicament containing the same. The compound represented by the formula: wherein A 3 is CR 3A , CR 3A R 3B , N or NR 3C ; R 3A , R 3B , R 4A and R 4B are each independently...

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Main Authors TOMIDA, Yutaka, SUGIYAMA, Shuichi, KAWASUJI, Takashi, MATSUMURA, Akira, TAMURA, Yoshinori, AKIYAMA, Toshiyuki
Format Patent
LanguageEnglish
French
German
Published 21.11.2018
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides a novel compound having antiviral activity, especially HIV replication inhibitory activity and a medicament containing the same. The compound represented by the formula: wherein A 3 is CR 3A , CR 3A R 3B , N or NR 3C ; R 3A , R 3B , R 4A and R 4B are each independently a hydrogen atom, halogen, cyano, substituted or unsubstituted alkyl, substituted or unsubstituted alkynyl, or substituted or unsubstituted non-aromatic carbocyclyl; R 3C is a hydrogen atom, substituted or unsubstituted alkyl, or substituted or unsubstituted non-aromatic carbocyclyl; ring T 1 is substituted or unsubstituted nitrogen-containing non-aromatic heterocycle; R 1 is a hydrogen atom, halogen, cyano, or substituted or unsubstituted alkyl; R 2 is each independently substituted or unsubstituted alkyl or the like: n is 1 or 2; R 3 is substituted or unsubstituted aromatic carbocyclyl or the like; R 4 is a hydrogen atom or a carboxy protecting group.
Bibliography:Application Number: EP20160803241