COMPOSITION, CONTAINING LITHOSPERMI RADIX EXTRACT AS ACTIVE INGREDIENT, FOR PREVENTING, ALLEVIATING, OR TREATING PERIPHERAL NEUROPATHY

• Main Authors: YI, Jin-Mu, CHO, Eun-Sang, KIM, Jinhee, KIM, Youngah, KIM, No Soo, PARK, Jong-Shik, LIM, Chae Jun, LEE, You Jin, BANG, Ok-Sun
• Format: Patent
• Language: English; French; German
• Published: 19.08.2020
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to a composition for preventing, alleviating, or treating peripheral neuropathy, in particular, peripheral neuropathy induced by an anti-cancer agent (i.e., chemotherapy-induced peripheral neuropathy), comprising a Lithospermi Radix extract as an effective component. Specifically, the Lithospermi Radix extract can relieve the suppressed growth of neurites caused by an anti-cancer agent while neither inducing any cytotoxicity in normal cells nor changing the unique cytotoxic potential of an anti-cancer agent in human cancer cells. In addition the Lithospermi Radix extract can efficiently lower the enhanced sensitivity to painful stimuli in peripheral neuropathic animals induced by an anti-cancer agent. Thus, the Lithospermi Radix extract can be advantageously used as an effective component of a composition for prevention, alleviation, or treatment of chemotherapy-induced peripheral neuropathy.