COMPOSITION, CONTAINING LITHOSPERMI RADIX EXTRACT AS ACTIVE INGREDIENT, FOR PREVENTING, ALLEVIATING, OR TREATING PERIPHERAL NEUROPATHY
The present invention relates to a composition for preventing, alleviating, or treating peripheral neuropathy, in particular, peripheral neuropathy induced by an anti-cancer agent (i.e., chemotherapy-induced peripheral neuropathy), comprising a Lithospermi Radix extract as an effective component. Sp...
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Main Authors | , , , , , , , , |
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Format | Patent |
Language | English French German |
Published |
21.03.2018
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Subjects | |
Online Access | Get full text |
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Summary: | The present invention relates to a composition for preventing, alleviating, or treating peripheral neuropathy, in particular, peripheral neuropathy induced by an anti-cancer agent (i.e., chemotherapy-induced peripheral neuropathy), comprising a Lithospermi Radix extract as an effective component. Specifically, the Lithospermi Radix extract can relieve the suppressed growth of neurites caused by an anti-cancer agent while neither inducing any cytotoxicity in normal cells nor changing the unique cytotoxic potential of an anti-cancer agent in human cancer cells. In addition the Lithospermi Radix extract can efficiently lower the enhanced sensitivity to painful stimuli in peripheral neuropathic animals induced by an anti-cancer agent. Thus, the Lithospermi Radix extract can be advantageously used as an effective component of a composition for prevention, alleviation, or treatment of chemotherapy-induced peripheral neuropathy. |
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Bibliography: | Application Number: EP20150891955 |