CATIONIC STEROIDAL ANTIMICROBIAL SALTS

Disclosed herein are acid addition salts of cationic steroidal antimicrobials ("CSAs" or "ceragenins") and methods of making the same. Particularly advantageous salt forms are identified, such as 1,5-naphthalenedisulfonic acid addition salts and sulfate addition salts. The acid a...

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Bibliographic Details
Main Authors SAVAGE, Paul B, RANDALL, Jared Lynn, JACKS, Thomas Elliot, VARIA, Kunal Arvind, REECE, Hayley Ann, CHITRE, Saurabh Shashikant, MILLER, Ross Allen
Format Patent
LanguageEnglish
French
German
Published 26.12.2018
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
STEROIDS
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Summary:Disclosed herein are acid addition salts of cationic steroidal antimicrobials ("CSAs" or "ceragenins") and methods of making the same. Particularly advantageous salt forms are identified, such as 1,5-naphthalenedisulfonic acid addition salts and sulfate addition salts. The acid addition salts may be formulated for treating subjects with ailments responsive to CSAs, including but not limited to treating bacterial infections. Embodiments include formulations and methods of administering acid addition salts of CSAs.
Bibliography:Application Number: EP20160783970