ARTIFICIAL TYMPANIC MEMBRANE DEVICES AND USES

• Main Authors: LEWIS, Jennifer, ROSOWSKI, John, SKYLAR-SCOTT, Mark A, REMENSCHNEIDER, Aaron K, KOLESKY, David, VALENTINE, Alexander D, MCKENNA, Michael J, LEE, Daniel J, KOZIN, Elliott, BLACK, Nicole
• Format: Patent
• Language: English; French; German
• Published: 05.12.2018
• Subjects: BANDAGES, DRESSINGS OR ABSORBENT PADS; BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF,TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ENZYMOLOGY; FILTERS IMPLANTABLE INTO BLOOD VESSELS; FIRST-AID KITS; FOMENTATION; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; PROSTHESES; SPIRITS; TREATMENT OR PROTECTION OF EYES OR EARS; VINEGAR; WINE

This disclosure features artificial tympanic membrane graft devices and two-component bilayer graft devices that include a scaffold having a plurality of ribs made of a first material and a plurality of spaces between the ribs filled or made with the first material, a different, second material, a combination of the first and a second materials, or a combination of a second material and one or more other different materials. The bilayer graft devices have two components or layers. One component, e.g., the underlay graft device, can include a projection, and the second component, e.g., the overlay graft device, can include an opening that corresponds to the projection (or vice versa) so that the opening and the projection can secure the two layers together in a "lock and key" manner. This disclosure also features methods of making, using, and implanting the three-dimensional artificial tympanic membrane and bilayer graft devices.