ALBUMIN VARIANTS AND CONJUGATES

Based on the three-dimensional structure of albumin, the inventors have designed variant polypeptides (muteins) which have one or more cysteine residues with a free thiol group (hereinafter referred to as "thio-albumin"). The variant polypeptide may be conjugated through the sulphur atom o...

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Bibliographic Details
Main Authors CAMERON, Jason, FRIIS, Esben, Peter, HAY, Joanna, Mary, SLEEP, Darrell, FINNIS, Christopher, John, Arthur
Format Patent
LanguageEnglish
French
German
Published 10.04.2024
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:Based on the three-dimensional structure of albumin, the inventors have designed variant polypeptides (muteins) which have one or more cysteine residues with a free thiol group (hereinafter referred to as "thio-albumin"). The variant polypeptide may be conjugated through the sulphur atom of the cysteine residue to a conjugation partner such as a bioactive compound.
Bibliography:Application Number: EP20170156183