RNA INTERFERENCE COMPOSITIONS AND METHODS FOR MALIGNANT TUMORS

This invention provides compositions for use in distributing active agents for treating a malignant tumor in a subject. The compositions contain RNAi molecules targeted to a human GST-π, along with RNAi molecules targeted to a human p21, and a pharmaceutically acceptable carrier. The carrier can inc...

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Bibliographic Details
Main Authors NIITSU, Yoshiro, LIU, Jihua, YING, Wenbin, ADAMI, Roger, MINOMI, Kenjirou, WANG, Li, MAJETI, Bharat
Format Patent
LanguageEnglish
French
German
Published 08.11.2017
Subjects
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Summary:This invention provides compositions for use in distributing active agents for treating a malignant tumor in a subject. The compositions contain RNAi molecules targeted to a human GST-π, along with RNAi molecules targeted to a human p21, and a pharmaceutically acceptable carrier. The carrier can include nanoparticles composed of an ionizable lipid, a structural lipid, one or more stabilizer lipids, and a lipid for reducing immunogenicity of the nanoparticles. This invention further provides methods for preventing or treating a malignant tumor by administering a therapeutically effective amount of an RNAi composition
Bibliography:Application Number: EP20150874366