SOLUBLE UNIVERSAL ADCC-ENHANCING SYNTHETIC FUSION GENE AND PEPTIDE TECHNOLOGY AND ITS USE THEREOF

Novel synthetic biology-based ADCC technologies are provided that enhance or enable ADCC responses, for example, through a rationally-designed soluble universal ADCC enhancer protein (SUAEP) where a high-affinity CD3-binding domain is fused to a high-affinity Fc-binding domain. The SUAEP technology...

Full description

Saved in:
Bibliographic Details
Main Authors LI, Chiang J, UNNIRAMAN, Shyam
Format Patent
LanguageEnglish
French
German
Published 18.10.2017
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
Online AccessGet full text

Cover

More Information
Summary:Novel synthetic biology-based ADCC technologies are provided that enhance or enable ADCC responses, for example, through a rationally-designed soluble universal ADCC enhancer protein (SUAEP) where a high-affinity CD3-binding domain is fused to a high-affinity Fc-binding domain. The SUAEP technology can be used to prevent or treat cancers, infectious, inflammatory or autoimmune diseases, and other diseases where elimination of diseased cells is desirable.
Bibliography:Application Number: EP20150867381