METHOD FOR PRODUCING CRYSTALS OF DIAZABICYCLOOCTANE DERIVATIVE AND STABLE LYOPHILIZED PREPARATION

The objects of the present invention are to provide a process for producing crystals of compound (I) easily in an industrial scale, and a stable lyophilized composition of compound (I). It has been found that subjecting an aqueous solution containing compound (I) and an inorganic salt such as sodium...

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Bibliographic Details
Main Authors ICHIKI, Masato, YOKOYAMA, Takuya, FUSHIHARA, Kenichi, FURUYAMA, Shusuke, OGAWA, Takaya
Format Patent
LanguageEnglish
French
German
Published 02.05.2018
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The objects of the present invention are to provide a process for producing crystals of compound (I) easily in an industrial scale, and a stable lyophilized composition of compound (I). It has been found that subjecting an aqueous solution containing compound (I) and an inorganic salt such as sodium chloride to lyophilization yields a lyophilized composition having good storage stability wherein the compound (I) is crystalline, and further that crystals of compound (I) can be obtained from said aqueous solution without lyophilization.
Bibliography:Application Number: EP20150866317