4,6-SUBSTITUTED-PYRAZOLO[1,5-A]PYRAZINES AS JANUS KINASE INHIBITORS

Compounds of Formula I:and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R1, R2, R3 and R4 have the meanings given in the specification, are inhibitors of one or more JAK kinases and are useful in the treatment of JAK kinase-associated diseases and disorders, such...

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Main Authors RAHEJA, Raj K, LAIRD, Ellen, KRASER, Christopher F, PHENEGER, Jed, BENNETT, Brydon L, CHICARELLI, Mark J, HINKLIN, Ronald Jay, ALLEN, Shelley, ROBINSON, John E, LEFTHERIS, Katerina, FISCHER, John P, SATOH, Yoshitaka, HICKEN, Erik James, BURGESS, Laurence E, FELL, Jay Bradford, RIEGER, Robert Andrew, BOYS, Mark Laurence, GAUDINO, John, TANG, Tony P
Format Patent
LanguageEnglish
French
German
Published 20.01.2021
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Compounds of Formula I:and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R1, R2, R3 and R4 have the meanings given in the specification, are inhibitors of one or more JAK kinases and are useful in the treatment of JAK kinase-associated diseases and disorders, such as autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, as well as hematologic disorders and malignancies and their co-morbidities.
Bibliography:Application Number: EP20150819933