TRICYCLIC COMPOUNDS AS INHIBITORS OF MUTANT IDH ENZYMES

• Main Authors: HUANG, Chunhui, ELLIS, J. Michael, ESPOSITE, Sara, UJJAINWALLA, Feroze, CHILDERS, Matthew, L, SCIAMMETTA, Nunzio, FISCHER, Christian, LAMPE, John, W, OTTE, Ryan, D, SLOMAN, David, L, PARKER, Dann, L., Jr, REUTERSHAN, Michael, WHITE, Catherine, BOGEN, Stephane, L, LLINAS, Francesc Xavier Fradera, HONG, Qingmei, MACHACEK, Michelle, R, WU, Zhicai, SHAO, Pengcheng, P, MCMASTERS, Daniel, R, KIM, Alexander, J
• Format: Patent
• Language: English; French; German
• Published: 01.07.2020
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; CHEMISTRY; FISHING; FORESTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HUNTING; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF; TRAPPING

The present invention is directed to tricyclic compounds of formula (I) which are inhibitors of one or more mutant IDH enzymes: (I). The present invention is also directed to uses of the tricyclic compounds described herein in the potential treatment or prevention of cancers in which one or more mutant IDH enzymes are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such cancers.