INHIBITORY CHIMERIC ANTIGEN RECEPTORS

The invention relates to an inhibitory chimeric antigen receptor (N-CAR) comprisingan extracellular domain comprising an antigen binding domain,a transmembrane domain and,an intracellular domainwherein the intracellular domain comprises an Immunoreceptor Tyrosine-based Switch Motif ITSM, wherein sai...

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Bibliographic Details
Main Authors JUILLERAT, Alexandre, PERTEL, Thomas Charles, POIROT, Laurent, STONE, Donna Marie, SASU, Barbra Johnson, RAJPAL, Arvind, POTLURI, Shobha Chowdary
Format Patent
LanguageEnglish
French
German
Published 20.09.2017
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The invention relates to an inhibitory chimeric antigen receptor (N-CAR) comprisingan extracellular domain comprising an antigen binding domain,a transmembrane domain and,an intracellular domainwherein the intracellular domain comprises an Immunoreceptor Tyrosine-based Switch Motif ITSM, wherein said ITSM is a sequence of amino acid TX1YX2X3X4, whereinX1 is an amino acidX2 is an amino acidX3 is an amino acid andX4 is V or I.
Bibliography:Application Number: EP20150798238