INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascul...

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Bibliographic Details
Main Authors DONG, Shuzhi, JIANG, Jinlong, SUZUKI, Takao, GU, Xin, YU, Yang, BLIZZARD, Timothy A, SHI, Zhi-Cai, PASTERNAK, Alexander, FERGUSON, Ronald II, WALSH, Shawn P, GUO, Zhiqiang, FU, Qinghong, WU, Zhicai, FRIE, Jessica, VANGELDER, Kelsey F
Format Patent
LanguageEnglish
French
German
Published 16.05.2018
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.
Bibliography:Application Number: EP20150854604