METHOD FOR CONSTRUCTING SEQUENCING LIBRARY BASED ON BLOOD SAMPLE AND USAGE THEREOF IN DETERMINING FETAL GENETIC ABNORMALITY

The present invention provides use of an oligonucleotide vesicular adaptor for constructing a cyclic single-stranded nucleic acid library having a vesicular non-paired region between a 5'-paired double-stranded region at a first terminal and a 3'-paired double-stranded region at a second t...

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Main Authors JIANG, Hui, ZHANG, Yanyan, GUO, Yulai, BALLINGER, Dennis G, CHEN, Fang, BASHKIROV, Vladimir I, SETHI, Himanshu, ZENG, Peng, XU, Xun, YANG, Huanming
Format Patent
LanguageEnglish
French
German
Published 19.07.2017
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Summary:The present invention provides use of an oligonucleotide vesicular adaptor for constructing a cyclic single-stranded nucleic acid library having a vesicular non-paired region between a 5'-paired double-stranded region at a first terminal and a 3'-paired double-stranded region at a second terminal region as further defined herein.
Bibliography:Application Number: EP20140901739