MONOCYCLIC ISOXAZOLINES AS INHIBITORS OF CHOLESTEROL ESTER TRANSFER PROTEIN
Compounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, wherein Dl, D2 and D3 are each N, CH, or substituted CH, are CETP inhibitors and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis...
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| Main Authors | , , , |
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| Format | Patent |
| Language | English French German |
| Published |
23.06.2021
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Compounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, wherein Dl, D2 and D3 are each N, CH, or substituted CH, are CETP inhibitors and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. |
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| AbstractList | Compounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, wherein Dl, D2 and D3 are each N, CH, or substituted CH, are CETP inhibitors and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. |
| Author | SHAO, Pengcheng Patrick THATAI, Jayanth Thiruvellore YE, Feng VACHAL, Petr |
| Author_xml | – fullname: THATAI, Jayanth Thiruvellore – fullname: VACHAL, Petr – fullname: SHAO, Pengcheng Patrick – fullname: YE, Feng |
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| DocumentTitleAlternate | ISOXAZOLINES MONOCYCLIQUES UTILISÉES COMME INHIBITEURS DE LA PROTÉINE DE TRANSFERT DES ESTERS DE CHOLESTÉROL MONOCYCLISCHE ISOXAZOLINE ALS HEMMER DES CHOLESTERINESTERTRANSFERPROTEINS |
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| RelatedCompanies | Merck Sharp & Dohme Corp |
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| Snippet | Compounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, wherein Dl, D2 and D3 are each N, CH, or substituted... |
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| SubjectTerms | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| Title | MONOCYCLIC ISOXAZOLINES AS INHIBITORS OF CHOLESTEROL ESTER TRANSFER PROTEIN |
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