SITE SPECIFIC PROTEIN MODIFICATIONS

The present invention relates to method and reagents for use in site-selective modification of protein and peptide. The site selective modification is a selective derivation of the amino functionality at the N-terminus of the protein or the polypeptide using the presence of a neighboring histidine a...

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Bibliographic Details
Main Authors YUAN, Jun, LOU, Changgang, USERA, Aimee Richardson
Format Patent
LanguageEnglish
French
German
Published 26.04.2017
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:The present invention relates to method and reagents for use in site-selective modification of protein and peptide. The site selective modification is a selective derivation of the amino functionality at the N-terminus of the protein or the polypeptide using the presence of a neighboring histidine amino acid to increase the reactivity of the N-terminal amino functionality. The modified proteins or peptides obtained by method of the invention may be used for imaging study or therapeutic uses.
Bibliography:Application Number: EP20150733963