PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF A PDE10 INHIBITOR

The present invention is directed to an improved process for the preparation of compounds of Formula (II) and Formula (III), which are useful in the inhibition of PDE10. In particular, the present invention is directed to an improved process for the preparation of 1-(5-(4-chloro-3,5-dimethoxyphenyl)...

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Main Authors MCDERMOTT, Michael James, CUTSHALL, Neil S, LITTLE, Thomas L, BROT, Elisabeth C.A, LUKE, Wayne Douglas, GAGE, Jennifer Lynn, REINEKE, Karl E, JONAS, Marco
Format Patent
LanguageEnglish
French
German
Published 27.12.2017
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention is directed to an improved process for the preparation of compounds of Formula (II) and Formula (III), which are useful in the inhibition of PDE10. In particular, the present invention is directed to an improved process for the preparation of 1-(5-(4-chloro-3,5-dimethoxyphenyl)furan-2-yl)-2-ethoxy-2-(4-(5-methyl-1,3,4-thiadiazol-2-yl)phenyl)ethanone, which is useful in the inhibition of PDE10.
Bibliography:Application Number: EP20150785376