SINGLE-CHAIN TRAIL-RECEPTOR AGONIST PROTEINS

Provided herein are specific TRAIL receptor agonist proteins, nucleic acids encoding the same, and methods of treating a subject having a TRAIL-associated disease or disorder. The TRAIL receptor agonist proteins provided herein comprise three soluble TRAIL domains and an Fc fragment. The TRAIL recep...

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Bibliographic Details
Main Authors PHILLIPS, Darren, C, LAPPE, Susan, E, BUCHANAN, Fritz, G, GIEFFERS, Christian, THIEMANN, Meinolf, HILL, Oliver
Format Patent
LanguageEnglish
French
German
Published 21.03.2018
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Provided herein are specific TRAIL receptor agonist proteins, nucleic acids encoding the same, and methods of treating a subject having a TRAIL-associated disease or disorder. The TRAIL receptor agonist proteins provided herein comprise three soluble TRAIL domains and an Fc fragment. The TRAIL receptor agonist proteins are substantially non-aggregating and suitable for therapeutic, diagnostic and/or research applications.
Bibliography:Application Number: EP20150721089