PROGNOSIS METHOD OF AUTOIMMUNE DISEASES BY GENOTYPING GENETIC VARIATIONS OF THE VASOACTIVE INTESTINAL PEPTIDE

• Main Authors: JUARRANZ MORATILLA, Yasmina, GONZALEZ ALVARO, Isidoro, MARTINEZ MORA, María del Carmen, LAMANA DOMINGUEZ, Amalia, LECETA MARTINEZ, Javier, PEREZ GOMARIZ, Rosa, ORTIZ GARCIA, Ana María
• Format: Patent
• Language: English; French; German
• Published: 25.01.2017
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPIRITS; VINEGAR; WINE

The present invention relates to a prognosis method for determining the severity of autoimmune diseases, for example, rheumatoid arthritis, spondyloarthritis and systemic lupus erythematosus, characterized in that it comprises detecting certain genetic polymorphisms of the VIP gene including, among others, rs35643203, rs71575932 and/or rs7755568. The method of the invention is also useful for establishing a customized patient treatment. The invention also relates to the use of the genetic polymorphisms of the VIP gene described in the invention as biomarkers of said diseases, as well as to a kit comprising primers or probes for detecting said polymorphisms and to the use thereof for the same purpose.