BETA-HAIRPIN PEPTIDES HAVING ANTI-VIRAL PROPERTIES AGAINST THE DENGUE VIRUS

The present invention discloses structurally constrained synthetic peptides that have been optimized for the formation of a beta hairpin structure. Said peptides are able to inhibit or attenuate Dengue virus (DENV) infections. The invention also discloses pharmaceutical compositions containing these...

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Main Authors GARAY PÉREZ, Hilda Elisa, HUERTA GALINDO, Vivian, GARATEIX SUÁREZ, Rocio, REYES ACOSTA, Osvaldo, GONZÁLEZ LÓPEZ, Luis Javier, SARRÍA NÚÑEZ, Mónica, CHINEA SANTIAGO, Glay, PUPO GÓMEZ, Dianne, ALVAREZ PÉREZ, Karen, YERO DÍAZ, Alexis, GONZÁLEZ BLANCO, Sonia, GUIROLA CRUZ, Osmany, VÁZQUEZ CASTILLO, Mariela, MARTÍN DUNN, Alejandro, Miguel, FALCÓN CAMA, Viviana, MÁRQUEZ PERERA, Gabriel Jesús
Format Patent
LanguageEnglish
French
German
Published 03.04.2019
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention discloses structurally constrained synthetic peptides that have been optimized for the formation of a beta hairpin structure. Said peptides are able to inhibit or attenuate Dengue virus (DENV) infections. The invention also discloses pharmaceutical compositions containing these synthetic peptides, which are useful for the prevention and/or treatment of DENV-caused infections. Likewise, the invention disclosed a method for treating infections caused by this virus.
Bibliography:Application Number: EP20150718758