MACROCYCLIC FACTOR XIA INHIBITORS CONDENSED WITH HETEROCYCLES

or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising thes...

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Bibliographic Details
Main Authors CORTE, James, R, ZHU, Yeheng, SMITH II, Leon, M, EWING, William, R, WEXLER, Ruth, R, DILGER, Andrew, K, PABBISETTY, Kumar Balashanmuga, YANG, Wu, PINTO, Donald, J.P, WANG, Yufeng, FANG, Tianan, ORWAT, Michael, J, DE LUCCA, Indawati
Format Patent
LanguageEnglish
French
German
Published 07.12.2016
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
Bibliography:Application Number: EP20150705427