METHOD FOR PREPARING HYDROXYPROPYL METHYLCELLULOSE ACETATE SUCCINATE (HPMCAS) GRAINS HAVING CONTROLLED GRAIN SIZE DISTRIBUTION, AND HPMCAS POWDER

Disclosed are a method for preparing hydroxypropyl methylcellulose acetate succinate (HPMCAS) grains and HPMCAS grains. The disclosed method for preparing HPMCAS grains comprises: a step of esterifying hydroxypropyl methylcellulose (HPMC), acetic anhydride, and succinic anhydride in a reaction mediu...

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Bibliographic Details
Main Authors SON, Jin Ryul, JEONG, Ji Seon, BANG, Sung Hwan, LEE, Sang Youb, SHIN, Ju Hee, PARK, Kyung Yeol, CHUN, Jeong Hee
Format Patent
LanguageEnglish
French
German
Published 26.01.2022
Subjects
CHEMISTRY
COMPOSITIONS BASED THEREON
DERIVATIVES THEREOF
METALLURGY
ORGANIC MACROMOLECULAR COMPOUNDS
POLYSACCHARIDES
THEIR PREPARATION OR CHEMICAL WORKING-UP
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Summary:Disclosed are a method for preparing hydroxypropyl methylcellulose acetate succinate (HPMCAS) grains and HPMCAS grains. The disclosed method for preparing HPMCAS grains comprises: a step of esterifying hydroxypropyl methylcellulose (HPMC), acetic anhydride, and succinic anhydride in a reaction medium in the presence of a catalyst so as to obtain a reaction solution containing HPMCAS (esterification step); and a step of continuously or intermittently putting the reaction solution into water so as to form grains (granulating step).
Bibliography:Application Number: EP20140877031