RETINOID-LIPOSOMES FOR ENHANCING MODULATION OF HSP47 EXPRESSION

What is described are pharmaceutical compositions comprising a double-stranded nuclei acid molecule comprising a sense strand and an antisense strand wherein the sense and antisense strands are selected from the oligonucleotides described as SERPINH1_2 (SEQ ID NOS: 60 and 127), SERPTNH1-45a (SEQ ID...

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Bibliographic Details
Main Authors PAYNE, JOSEPH E, AKOPIAN, VIOLETTA, MINOMI, KENJIRO, KNOPOV, VICTOR, AHMADIAN, MOHAMMAD, PERELMAN, LOREN A, AVKIN-NACHUM, SHARON, TANAKA, YASUNOBU, FEINSTEIN, ELENA, METT, IGOR, KALINSKI, HAGAR, LUI, YUN, WITTE, RICHARD P, YING, WENBIN, NIITSU, YOSHIRO
Format Patent
LanguageEnglish
French
German
Published 05.10.2016
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:What is described are pharmaceutical compositions comprising a double-stranded nuclei acid molecule comprising a sense strand and an antisense strand wherein the sense and antisense strands are selected from the oligonucleotides described as SERPINH1_2 (SEQ ID NOS: 60 and 127), SERPTNH1-45a (SEQ ID NOS: 98 and 165), and SERPTNH1_51 (SEQ ID NOS: 101 and 168), and drug carrier comprising a mixture of a retinoid and a lipid vesicle, and methods of using these pharmaceutical compositions to treat a disease associated with hsp47 expression, including fibrosis.
Bibliography:Application Number: EP20160169874