MULTI-COMPONENT INHIBITORS OF NUCLEIC ACID POLYMERASES AND METHODS THEREWITH
The present invention provides multi-component inhibitors of nucleic acid polymerases, methods of making, and methods of using same. One component of the multi-component inhibitor is a molecule that binds to a polymerase (i.e., a polymerase-binding molecule (PBM)), but does not thereby substantially...
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Main Authors | , |
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Format | Patent |
Language | English French German |
Published |
17.08.2016
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Subjects | |
Online Access | Get full text |
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Summary: | The present invention provides multi-component inhibitors of nucleic acid polymerases, methods of making, and methods of using same. One component of the multi-component inhibitor is a molecule that binds to a polymerase (i.e., a polymerase-binding molecule (PBM)), but does not thereby substantially inhibit its polymerase activity. Another component is a molecule or complex of molecules that binds to a PBM (i.e., a PBM-binding molecule). The combination of the PBM and PBM-binding molecule/complex substantially inhibits polymerase activity. |
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Bibliography: | Application Number: EP20150199782 |