IL-1 BETA FOR THE PRO-INFLAMMATORY STIMULATION OF A CUTANEOUS SUBSTITUTE OR EXPLANT

The present invention relates to the use of a pro-inflammatory stimulating reagent containing between 10 and 500 ng/mL of interleukin IL-1β to reproduce the physiopathology of atopic dermatitis in vitro and/or to alter the barrier function in a cutaneous substitute or a cutaneous explant. It also re...

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Bibliographic Details
Main Authors GALLIANO, Marie-Florence, BERNARD, Marine
Format Patent
LanguageEnglish
French
German
Published 14.10.2020
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PHYSICS
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
TESTING
VINEGAR
WINE
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Summary:The present invention relates to the use of a pro-inflammatory stimulating reagent containing between 10 and 500 ng/mL of interleukin IL-1β to reproduce the physiopathology of atopic dermatitis in vitro and/or to alter the barrier function in a cutaneous substitute or a cutaneous explant. It also relates to a pro-inflammatory stimulating reagent containing: a. Between 10 and 500 ng/mL interleukin IL-1β, and b. Between 3 and 20 µg/mL of a ligand of the TLR-2 receptor, and/or c. Between 3 and 20 µg/mL of a ligand of the TLR-3 receptor.
Bibliography:Application Number: EP20140747616